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KMID : 1098420090170010061
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Korean Journal of Medicinal Crop Science
2009 Volume.17 No. 1 p.61 ~ p.67
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Antimicrobial Agent from Schima wallichii ssp. liukiuensis against Candida spp.
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Shin Kuem
Min Ji-Yun
Kang Seung-Mi
Park Dong-Jin
Song Hyun-Jin
Kwon Oh-Woung
Yang Jae-Kyung
Choi Myung-Suk
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Abstract
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This study carried out development of a natural antimicrobial agent from Schima wallichii ssp. liukiuensis. Compound I exhibiting potent antimicrobial activity against Candida spp. was isolated from the methanol extracts of Schima wallichii ssp. liukiuensis. The structure of I identified as a sterol glycoside consisted of a trisaccharide and α1-sitosterol. Trisaccharide composed of L-rhamnose, D-galactose and D-glucose residues. The antimicrobial activity of I was selective on yeast rather than bacteria or other fungi. Compound I was demonstrated to be ineffective against toxicity to mouse liver cells where as protective to human dermal fibroblast cells at low concentrations. Thus, it is reasonable to expect a sterol glycoside (I) as a valuable alternative for synthetic antifungal.
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KEYWORD
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Schima wallichii ssp. liukiuensis, Antimicrobial, Sterol glycoside, Candida spp.
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